Saliva-Based Drug Testing: Is it the Right Choice for Your Fleet?
Saliva-based drug testing will soon be an option for motor carriers when sending CDL drivers for U.S. Department of Transportation (DOT) testing. Do you know what to expect?

Oral-fluid drug testing detects more recent use, making it more advantageous for post-accident and reasonable suspicion tests
Photo: Work Truck
Saliva-based drug testing will soon be an option for motor carriers when sending CDL drivers for U.S. Department of Transportation (DOT) testing.
Regulations allow the testing as of June 1, but this testing likely may not be an option until late 2023 or early 2024.
Why the Delay in Testing Implementation?
Saliva-based drug tests cannot begin until:
Two separate laboratories have received government approval to process oral-fluid specimens (none are approved yet); and
Collectors have been trained to use whichever saliva collection devices the labs will allow.
The Health and Human Services (HHS) approval process for laboratories takes several months.
Pros & Cons of Saliva Drug Testing
Large and small fleets must decide whether saliva testing is suitable for drivers.
Fleets should consider the following when weighing their options:
The true cost of testing. It remains to be seen whether saliva tests will cost more or less than urine tests. The overall cost may be cheaper when you factor in some of the benefits of saliva testing, such as eliminating cheating and using a saliva test when a driver cannot provide a urine sample (eliminating the need for a medical exam). Ask your service agents to compare fees as you decide whether saliva testing fits your operation.
The window of detection. Oral-fluid drug testing detects more recent use, making it more advantageous for post-accident and reasonable suspicion tests. It may not be as suitable for other test types, such as pre-employment or random when determining whether a driver is a chronic/habitual drug user. If you use oral-fluid drug testing, consider a hybrid model in your overall program that takes advantage of both test types.
Cheating. Oral-fluid drug testing offers fewer opportunities to tamper with the specimen or otherwise cheat on the test. Every oral-fluid specimen collection is directly observed.
Privacy. Compared to urine collections, oral-fluid testing is not as intrusive. In part, this means drivers may be less hesitant to undergo a test.
Preparing for the Switch
If you decide to use oral-fluid drug testing, fleets must perform some tasks in preparation, such as:
Update your company’s DOT testing policy to indicate the following:
Which test types apply to saliva-based testing, and
Which test types apply to a urine sample.
Provide existing CDL drivers with a revised DOT drug and alcohol policy/educational materials, letting them know what to expect at the collection site. Collect a new signed receipt from them after distribution.
Train the designated employer representative (DER) on oral-fluid drug testing procedures, including which test types require the testing method based on policy. The DER must communicate to the collection site whether the drug test should be a urine or saliva-based sample.
Find the right service agents. If saliva-based drug testing works for your company, you need to:
Confirm that your collection site offers oral-fluid drug testing or seek out another vendor.
Contract with an HHS-certified lab to process oral-fluid drug tests.
Contract with a certified medical review officer who verifies oral-fluid drug tests.
Closing Thoughts
Even though the option of oral-fluid testing is months away, now is the time to decide whether it is a fit for your operation.
You should immediately line up service providers, train your staff, and update your policies. Create a plan to help move forward once the green light is given for testing.
More Safety

5 Safe Driving Tips for 4th of July
To ensure that this year’s fireworks remain in the sky and not on the roadway, follow these five easy steps to remain safe on the road this year – shared directly from a truck driver.
Read More →
NSC Marks 30 Years of National Safety Month, Includes Road Safety Focus
The Staying Safe on the Roads topic is one of four weekly focuses in June as the National Safety Council observes the 30th anniversary of National Safety Month. NSC also provides insights on the need for fleets to create a safety policy.
Read More →
Fleetworthy Integrates Lytx Video Snapshots to Improve Driver Coaching
Fleetworthy’s integration of Lytx video snapshots enables fleet managers to combine visual event evidence with Safety+ risk data, helping them make faster, more informed coaching decisions without leaving the Fleetworthy platform.
Read More →
Recalls You Need to Know About in June 2026
In June 2026, what recalls might impact your fleet? Work Truck has the answers in this comprehensive overview of recent NHTSA recalls.
Read More →
J. J. Keller Safety Professional of the Year Awards Nominations Now Open
J. J. Keller & Associates is accepting nominations for the 2026 J. J. Keller Safety Professional of the Year (SPOTY) Awards. Winners will receive prize packages valued at up to $47,200.
Read More →
ASE Aligns Automotive Service Professionals Month With Spring and Fall Vehicle Maintenance Campaigns
ASE will move Automotive Service Professionals Month to April and October beginning in 2026-2027, aligning recognition with Car Care Month events.
Read More →
Turning Connected Vehicle Data Into Decisions That Matter
Fleet leaders have more data than ever, but turning that data into clear, actionable decisions remains a challenge. This white paper shows how leading organizations are using connected vehicle data to improve safety, reduce costs, and optimize fleet performance. Learn how to turn insight into action across your fleet.
Read More →
Driver Retention: Motive Automates Driver Coaching & Driver Rewards
New automated rewards and recognition capabilities from Motive can help organizations engage drivers, reinforce positive behavior, and reduce turnover. AI Coach has also been updated to deliver personalized feedback across safety, fuel, and compliance.
Read More →
Experts Forecast Broader Impact of Wildfires in 2026
This year’s wildfire season will likely be more intense than in 2025. The 2026 wildfire forecast from AccuWeather is for fewer fires, but even more acreage will be impacted this year.
Read More →
A Walkthrough of the DataQs Process
Bad data on your carrier record can cost you. Here’s how DataQs helps fleets challenge errors before they hit CSA scores, insurance, and your bottom line.
Read More →

