Saliva-Based Drug Testing: Is it the Right Choice for Your Fleet?
Saliva-based drug testing will soon be an option for motor carriers when sending CDL drivers for U.S. Department of Transportation (DOT) testing. Do you know what to expect?

Oral-fluid drug testing detects more recent use, making it more advantageous for post-accident and reasonable suspicion tests
Photo: Work Truck
Saliva-based drug testing will soon be an option for motor carriers when sending CDL drivers for U.S. Department of Transportation (DOT) testing.
Regulations allow the testing as of June 1, but this testing likely may not be an option until late 2023 or early 2024.
Why the Delay in Testing Implementation?
Saliva-based drug tests cannot begin until:
Two separate laboratories have received government approval to process oral-fluid specimens (none are approved yet); and
Collectors have been trained to use whichever saliva collection devices the labs will allow.
The Health and Human Services (HHS) approval process for laboratories takes several months.
Pros & Cons of Saliva Drug Testing
Large and small fleets must decide whether saliva testing is suitable for drivers.
Fleets should consider the following when weighing their options:
The true cost of testing. It remains to be seen whether saliva tests will cost more or less than urine tests. The overall cost may be cheaper when you factor in some of the benefits of saliva testing, such as eliminating cheating and using a saliva test when a driver cannot provide a urine sample (eliminating the need for a medical exam). Ask your service agents to compare fees as you decide whether saliva testing fits your operation.
The window of detection. Oral-fluid drug testing detects more recent use, making it more advantageous for post-accident and reasonable suspicion tests. It may not be as suitable for other test types, such as pre-employment or random when determining whether a driver is a chronic/habitual drug user. If you use oral-fluid drug testing, consider a hybrid model in your overall program that takes advantage of both test types.
Cheating. Oral-fluid drug testing offers fewer opportunities to tamper with the specimen or otherwise cheat on the test. Every oral-fluid specimen collection is directly observed.
Privacy. Compared to urine collections, oral-fluid testing is not as intrusive. In part, this means drivers may be less hesitant to undergo a test.
Preparing for the Switch
If you decide to use oral-fluid drug testing, fleets must perform some tasks in preparation, such as:
Update your company’s DOT testing policy to indicate the following:
Which test types apply to saliva-based testing, and
Which test types apply to a urine sample.
Provide existing CDL drivers with a revised DOT drug and alcohol policy/educational materials, letting them know what to expect at the collection site. Collect a new signed receipt from them after distribution.
Train the designated employer representative (DER) on oral-fluid drug testing procedures, including which test types require the testing method based on policy. The DER must communicate to the collection site whether the drug test should be a urine or saliva-based sample.
Find the right service agents. If saliva-based drug testing works for your company, you need to:
Confirm that your collection site offers oral-fluid drug testing or seek out another vendor.
Contract with an HHS-certified lab to process oral-fluid drug tests.
Contract with a certified medical review officer who verifies oral-fluid drug tests.
Closing Thoughts
Even though the option of oral-fluid testing is months away, now is the time to decide whether it is a fit for your operation.
You should immediately line up service providers, train your staff, and update your policies. Create a plan to help move forward once the green light is given for testing.
More Safety & Compliance

Navigating the Effects of Daylight Saving Time on Work Truck Fleets
Discover how daylight saving time impacts work truck fleets and get essential tips for fleet managers and drivers to navigate the "fall back" transition.
Read More →
How Halloween Changes the Job for Work Truck Drivers
Truck traffic doesn’t take the same Halloween break as other drivers. What fleet managers should know about timing, neighborhood stops, and braking data.
Read More →
Tips for Driving Safely on Halloween Night
This video features a reminder from the Connecticut Department of Transportation (DOT) and the Connecticut Police Chiefs Association, urging drivers to prioritize safety this Halloween.
Read More →From Our Partners

Re-rating Gross Vehicle Weight Ratings (GVWR): Why and How it's Done
Sometimes, it is not in a fleet’s best interests to have a vehicle at a given GVWR. Changing the GVWR to a special value can be done, but the process is complicated.
Read More →
When a Work Truck Gets Stolen, the Real Loss Is Time
A stolen work truck can take more than a vehicle off the road. From tools and access cards to crew downtime, here’s how fleets can prepare for theft before it disrupts the entire workday.
Read More →
Volvo Trucks Marks 25 Years as Exclusive Sponsor of America's Road Team
Volvo Trucks North America will serve as the exclusive sponsor of the American Trucking Associations' America's Road Team, marking 25 years of Volvo sponsorship. The group of professional drivers promotes safety and the industry as they travel the country.
Read More →
Streamlight’s High-Output Scene Light Recognized with Occupational Safety Award
Streamlight’s Portable Scene Light III (PSL III) won the 2026 Occupational Health & Safety (OH&S) New Product of the Year Award in the Lighting category.
Read More →
Fleetworthy Expands Expedited Inspection to 5 States
Following its industry-first launch in Nevada, Fleetworthy’s automated inspection technology is now live in California, Michigan, Vermont, and Maine.
Read More →
Crossing State Lines in a Light-Duty Work Truck? Check These Rules First
Crossing state lines in a lighter work truck? J.J. Keller's Kathy Close explains when IRP registration, trip permits, and towing rules come into play.
Read More →
Simple Tire Checks That Help Keep Your Business Fleet Moving
A survey found that nearly one in every 10 passenger vehicles has at least one bald tire. What's more, 27% -- more than one in four -- of vehicles are driven with one or more severely under-inflated tires.
Read More →



